Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus.
نویسندگان
چکیده
It is shown that rifampicin, and especially the related antibiotic 2',6'-dimethyl-N(4')-benzyl-N(4')- [desmethyl]rifampicin (DMB-rifampicin) can inhibit focus formation by Moloney sarcoma virus on BALB/3T3 tissue cultures. At 10 mug/ml DMB-rifampicin totally inhibits focus formation while reducing virus replication by at least a factor of fifty and cell proliferation by only a factor of three. These observations, taken together with those of others, suggest a role for an RNA-dependent DNA polymerase and the gene for its synthesis both in normal cell processes and in the transformation process.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 68 7 شماره
صفحات -
تاریخ انتشار 1971